Isomer separation and gas-phase configurations of organoruthenium anticancer complexes: Ion mobility mass spectrometry and modeling |
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| Authors: | Jonathan P. Williams Tijana Bugarcic Abraha Habtemariam Kevin Giles Iain Campuzano P. Mark Rodger Peter J. Sadler |
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| Affiliation: | (1) Department of Chemistry, University of Warwick, Gibbet Hill Road, CV4 7AL Coventry, UK;(2) Waters Corporation, Manchester, United Kingdom |
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| Abstract: | We have used ion mobility-mass spectrometry combined with molecular modeling for the separation and configurational analysis of three low-molecular-weight isomeric organoruthenium anticancer complexes containing ortho-, meta-, or para-terphenyl arene ligands. The isomers were separated using ion mobility based on traveling-wave technology and the experimentally determined collision cross sections were compared to theoretical calculations. Excellent agreement was observed between the experimentally and theoretically derived measurements. |
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