A new ginsengenin containing an oxacyclopentane-ring isolated from the acid hydrolysate of total ginsenosides |
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| Authors: | Qing-Xiang Guana De-Ya Suna Ji-Hua Liua Wei Lia b Qin Menga Cong Genga Jian-Yuan Yina a |
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| Institution: | School of Pharmacy,Jilin University,Changchun 130021,China b Beijing Laviana Pharmactech Co.,Ltd.,Beijing 102206,China |
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| Abstract: | Bioassay-guided fractionation of the acid hydrolysate of total ginsenosides of Panax ginseng C.A. Meyer (Araliaceae) led to the isolation of a novel ginsengenin (1). The structure of 1 was determined as (20S,22S)-dammar-22,25-epoxy-3β,12β,20-triol by extensive spectroscopy and single-crystal X-ray diffraction analyses. The cytotoxicity of 1 was further tested against SW1116, HCT116, and A549 cells by the MTT method, with IC50 values in the range of 2.96-30.9 μmol/L. |
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| Keywords: | Ginsengenin Oxacyclopentane Cytotoxicity |
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