Detection of human and rodent 5-HT3B receptor subunits by anti-peptide polyclonal antibodies |
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| Authors: | David C Reeves Sarah CR Lummis |
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| Affiliation: | (1) Department of Biochemistry, University of Cambridge, CB21QW Cambridge, UK;(2) Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USA |
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| Abstract: | Background The 5-HT3 receptor is a member of a neurotransmitter-gated ion channel family which includes nicotinic acetylcholine, GABAA, and glycine receptors. While antibodies specific for the 5-HT3A receptor subunit are plentiful, and have revealed a wealth of structural and functional information, few antisera exist for the detection of 5-HT3B receptor subunits. Here we describe the generation and characterisation of a rabbit polyclonal antiserum that specifically recognises 5-HT3B receptor subunits |
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