Synthesis and biological activities of novel ethers of quinolinone linked with coumarins |
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| Authors: | Rajesh G Kalkhambkar G Aridoss Geeta M Kulkarni R M Bapset T Y Mudaraddi N Premkumar and Yeon Tae Jeong |
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| Institution: | (1) Department of Chemistry, Karnatak Science College, Karnatak University, Dharwad, Karnataka, 580001, India;(2) Department of Chemistry, D.M.S Mandal’s Bhaurao Kakatkar Science College, Club Road, Belgaum, Karnataka, 590001, India;(3) Department of Biotechnology and Microbiology, Karnatak University, Dharwad, Karnataka, 580003, India;(4) Department of Pharmacology, Krupanidhi College of Pharmacy, Bangalore, Karnataka, 560034, India;(5) Department of Image Science and Engineering, Pukyong National University, Busan, 608-739, Republic of Korea; |
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| Abstract: | Abstract A series of new ethers of quinolinone linked with different substituted coumarins and benzofurans were synthesized from 4-(bromomethyl)quinolinones.
All newly synthesized compounds were screened for their in vitro antibacterial and antifungal activities. Most of the compounds
with chloro substitution at the C-6 or C-7 position in quinolinone showed potent antibacterial and antifungal activities.
In pharmacological evaluations, some of these chloroquinolinones also showed 70–77% inhibition of inflammation after 8 h,
whereas the other compounds showed 51–55% inhibition. Most of the compounds showed potent analgesic activity compared to the
standard and control. The structures of all newly synthesized compounds were characterized by elemental analysis, IR, 1H NMR, 13C NMR, and EI-MS. |
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