The synthesis of 13-hydroxylated ent-kaur-16-ene derivatives using an acyloin-like cyclization of keto esters |
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| Authors: | IF Cook JR Knox |
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| Institution: | Department of Organic Chemistry, University of Western Australia, Nedlands, Western Australia, 6009 |
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| Abstract: | The synthesis of steviol (27) and two A-ring modified analogues (9 and 15) is described. The synthetic sequences involve the preparation of suitably constituted 17-nor-13,16-seco-ent-kauranoid keto esters (22, 7 and 13) which are then cyclized to 13,16-dooxygenated-17-nor-ent-kauranes (23, 8 and 14). |
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