Photoresponsive Cross‐linked Polymeric Particles for Phototriggered Burst Release |
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| Authors: | Zhen Wang Lili Yu Cong Lv Peng Wang Yedong Chen Xinjing Tang |
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| Institution: | 1. State Key Laboratory of Natural & Biomimetic drugs, The School of Pharmaceutical Sciences, Peking University, , Beijing, 100191 China;2. School of Pharmaceutical Sciences, Xi′an Medical University, , Xi′an, 710021 Shanxi, China |
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| Abstract: | We synthesized a series of cross‐linked photoresponsive polymeric particles with photolabile monomers and cross‐linkers through miniemulsion polymerization. These particles are quite stable in dark, while light irradiation caused the breakage of particles and the efficient release of encapsulated contents up to 95% based on Nile red fluorescence. Photoswitches of particle systems were confirmed by fluorescence spectroscopy, SEM and colorimetry. Particle uptake and triggered release in RAW264.7 cells were confirmed by fluorescein diacetate loaded particles. |
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