Cyclometalated platinum(II) complexes containing monodentate phosphines: antiproliferative study |
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Authors: | Hamidreza Samouei Mehdi Rashidi Frank W. Heinemann |
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Affiliation: | 1. Chemistry Department, College of Sciences, Shiraz University, 71454, Shiraz, Iran 3. Institute of Chemical Research of Catalonia (ICIQ), 43007, Tarragona, Spain 2. Institut für Anorganische Chemie, Universit?t Erlangen-Nürnberg, Egerlandstrasse 1, 91058, Erlangen, Germany
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Abstract: | Reaction of cyclometalated platinum(II) precursor [Pt(C^N)Cl(dmso)], 1, C^N = N(1), C(2′)-chelated deprotonated 2-phenylpyridine and dmso = dimethylsulfoxide, with 1 equivalent of triphenyl phosphine, PPh3, or 1,3,5-triaza-7-phosphaadamantane, PTA, gave the complex [Pt(C^N)Cl(PPh3)], 2, or [Pt(C^N)Cl(PTA)], 3, respectively. On the basis of careful multinuclear NMR spectroscopy, supported by a number of 2D NMR experiments, structures of the complexes 2 and 3 in solution were determined to be neutral four coordinate. The X-ray crystallography indicated that the solid-state structure of complex 3 comprised a common square-planar geometry around platinum(II). Cytotoxicity of the complexes 2 and 3 was studied in three human cancer cell lines derived from ovarian carcinoma (CH1), lung carcinoma (A549), and colon carcinoma (SW480). |
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