High resolution printing of DNA feature on poly(methyl methacrylate) substrates using supramolecular nano-stamping |
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Authors: | Yu Arum Amy Savas Tim Cabrini Stefano Difabrizio Enzo Smith Henry I Stellacci Francesco |
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Institution: | Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, 02139, USA. |
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Abstract: | In recent years, a large number of devices based on organic and biological materials have been developed. To scale-up the production of these systems to industrially acceptable standards, there is a need to develop soft-material stamping approaches with the needed resolution, complexity, and versatility. We have recently developed a DNA-based stamping method (supramolecular nano-stamping, SuNS) that has superior resolution and can print multiple molecules at the same time. A similar technique was independently developed by Crooks and co-workers. Here we show that SuNS can be used to efficiently print DNA features on a polymeric substrate (poly(methyl methacrylate), PMMA) with a 40 nm point resolution and a coverage that exceeds 100 mum2. The stamped PMMA substrate was also used as a master to print on a gold substrate. With PMMA being optically clear and electrically insulating, future applications of SuNS to print DNA micro- and nanoarrays are envisioned. |
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