Ultrasound-assisted three-component synthesis of 3-(5-amino-1H-pyrazol-4-yl)-3-(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-enyl)indolin-2-ones in water |
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| Authors: | Afshin Rajabi Khorrami Fereshteh Faraji Ayoob Bazgir |
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| Institution: | 1. Department of Chemistry, Faculty of Sciences, Islamic Azad University, Karaj Branch, Tehran, Iran;2. Department of Chemistry, Shahid Beheshti University, GC, P.O. Box 19396-4716, Tehran, Iran |
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| Abstract: | Indium(III) chloride was found to be an efficient catalyst for the synthesis of 3-(5-amino-1H-pyrazol-4-yl)-3-(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-enyl)indolin-2-ones by one-pot, three-component reaction of dimedone, 1H-pyrazol-5-amines and isatins in water under ultrasonic irradiation. The advantages of this method are the use of a readily available catalyst, easy workup, excellent yields, and the use of water as a solvent that is considered to be relatively environmentally benign. |
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