A facile synthesis of deuteroporphyrins derivatives under ultrasound irradiation

A facile, efficient and general method for preparing deuteroporphyrin derivatives by using concentrated H₂SO₄ and alcohol under ultrasound irradiation has been developed. A series of new deuteroporphyrin derivatives bearing different propionic ester groups have been synthesized in good yields starting from readily accessible deuterohemin. The characterization of these compounds confirms the synthetic methodology. Compared with conventional methods, the main advantages of the present procedure are shorter reaction time and higher yields.