A convenient,rapid microwave assisted synthesis of some novel 3-[(4-chloro-3-methylphenoxy)methyl]-6-aryl-5,6-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles using acidic alumina |
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| Authors: | Jignesh P Raval Hemul V Patel Pradip S Patel Kishor R Desai |
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| Institution: | 1. Department of Pharmaceutical Chemistry, Ashok and Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences, New Vallabh Vidyanagar, 388 121 Anand, Gujarat, India;2. Department of Chemistry, Veer Narmad South Gujarat University, Udhna-Magdalla Road, Surat 395 001, Gujarat, India |
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| Abstract: | A facile synthesis of 3-(4-chloro-3-methylphenoxy)methyl]-6-aryl-5,6-dihydro-1,2,4]triazolo3,4-b]1,3,4]thiadiazoles 3a–n has been achieved by microwave promoted condensation of 3-mercapto-4-amino-5-(4-chloro-3-methylphenoxy)methyl]-4H-1,2,4-triazole 1 with various aromatic aldehydes 2a–n in presence of catalytic amount of p-TsOH (para-toluenesulphonic acid). The structures of 3a–n are supported by IR and 1H and 13C NMR spectral data. |
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| Keywords: | Microwave Acidic alumina |
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