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A Useful Disulfide Linker for Single‐Bead Analysis of Peptide Libraries |
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| Authors: | Oliver Lack Hans Zbinden Wolf‐D. Woggon |
| Abstract: | A disulfide‐linker for conventional peptide synthesis, attached to a PEGA‐resin, has been developed. Reductive hydrolysis cleaves the linker within minutes, liberating the synthesized peptide for rapid sequencing by tandem mass spectrometry. The method has been tested for ten peptides in a single‐bead fashion. |
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