Oligonucleosides with a Nucleobase‐Including Backbone,Part 7 |
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Authors: | PunitKumar Bhardwaj Andrea Vasella |
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Abstract: | The conformational analysis of 7 was carried out in (D6)DMSO and in mixtures of (D6)DMSO and CDCl3 to evaluate the syn/anti conformations, relevant to the pairing propensity of this type of nucleotide analogue. The HO?C(5′) of unit I and of unit II of the dimer 7 form an intramolecular H‐bond to N(3). In (D6)DMSO, the C(5′)?OH???N(3) H‐bond in unit I is partially broken, while that in unit II persists to a larger extent. The syn conformation prevails for unit I and particularly for unit II. The furanosyl moieties adopt predominantly a 2′‐endo conformation that is largely independent of the solvent. |
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