On the study of the dynamical aspects of parasitemia in the
blood cycle of malaria |
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Authors: | RM Zorzenon dos Santos S TR Pinho C P Ferreira P CA da Silva |
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Institution: | 1.Departamento de Física,Universidade Federal de Pernambuco,Recife,Brazil;2.Departamento de Física,Universidade Federal da Bahia,Salvador,Brazil;3.Departamento de Bioestatística,Universidade Estadual de S?o Paulo,Botucatu,Brazil |
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Abstract: | Malaria is an important cause of morbidity and mortality
worldwide. One striking aspect regarding malaria is the fact that
individuals living in endemic areas do not develop immunity
against the parasite, falling ill whenever they are exposed to
the parasite. The understanding of why immunity is not developed
in the usual way against Plasmodium is crucial to the improvement of
treatment and prevention. In this work, we study
some aspects of the dynamics of the blood cycle of malaria using
both modelling and data analysis of observed case-histories
described by parasitemia time series. By comparing our simulations
with experimental results we have shown that the different
behaviour observed among patients may be associated to
differences in the efficiency of the immune system to control the
infection. |
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Keywords: | |
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