Palladium-catalyzed coupling reaction of terminal alkynes with aryl iodides in the presence of indium tribromide and its application to a one-pot synthesis of 2-phenylindole |
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| Authors: | Sakai Norio Annaka Kimiyoshi Konakahara Takeo |
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| Affiliation: | Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science, Noda, Chiba 278-8510, Japan. sakachem@rs.noda.tus.ac.jp |
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| Abstract: | The use of a novel PdCl(2)(PPh(3))(2)-InBr(3) reagent system to catalyze cross-coupling reactions of a variety of aryl iodides with several terminal alkynes is described. The corresponding functional alkyne derivatives were produced in good to excellent yields. Moreover, a catalytic amount of InBr(3) effectively catalyzes the intramolecular cycloaddition of 2-phenylethynylaniline to form an indole skeleton in high yield. |
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