Synthesis and Reactions of Polyhedral Compounds. 27. Development of a Synthetic Route for 2- Spiro-substituted 6-Hydroxy-5,7-dimethyl-1,3-diazaadamantanes |
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Authors: | Ts Ye Aghajanian G L Arutyunian R K Shahkhatuni |
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Institution: | (1) Armenian Republic Academy of Sciences, A. L. Mndzhoyan Institute for Fine Organic Chemistry, Yerevan, 375014 |
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Abstract: | Alternative methods for the synthesis of 2-spiro-substituted 6-hydroxy-5,7-dimethyl-1,3-diazaadamantanes have been developed. These are the reduction of the ketone group to hydroxyl in the corresponding 6-oxo-1,3-diazaadamantanes and the condensation of 9-hydroxy-1,5-dimethyl-3,7-diazabicyclo3.3.1]nonane (obtained by different routes from 5,7-dimethyl-6-oxo-1,3-diazaadamantane) in reaction with cyclic ketones. |
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Keywords: | 3 7-diazabicyclo[3 3 1]nonane spiro-1 3-diazaadamantane cyclic ketones reduction condensation |
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