Purification of carbon-11 PET radiotracers from unlabeled precursors by preparative HPLC and SPE |
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| Authors: | Zheng Qi-Huang Mock Bruce H |
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| Affiliation: | Department of Radiology, Indiana University School of Medicine, 1345 West 16th Street, L-3 Room 202, Indianapolis, IN 46202-2111, USA. qzheng@iupui.edu |
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| Abstract: | A general methodology for the rapid purification of carbon-11 positron emission tomography (PET) radiotracers from radiolabeling reaction mixtures has been developed. Preparative HPLC and solid-phase extraction (SPE) techniques are described which can separate some commonly used radiopharmaceuticals such as [(11)C]raclopride, [(11)C]beta-CFT and [(11)C]choline from their unlabeled precursors. |
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| Keywords: | positron emission tomography carbon‐11 radiotracer HPLC SPE |
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