Synthesis and central nervous system stimulant activity of camphor-1,2,4-benzotriazines fused with five and six-membered heterocycles

Novel camphor-1,2,4-triazines fused with imidazole 2–3 , thiadiazole 4 , 1,2,4-triazole 7 , pyrimidine 9–13 and 1,3,5-triazine 14 , were synthesized starting from (5R,8S)-3-amino-5,9,9-trimethyl-5,6,7,8-tetrahydro-5,8-methano-1,2,4-benzotriazine 1 . Evaluation of central nervous system stimulant activity demonstrated that the presence of a N-N group at C-3 position of 1,2,4-benzotriazine will be essential for the activity.