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The preparation of 4-oxo-N-aryl-4H-1-benzopyran-2-acetamides by the condensation/cyclization of trilithiated acetoacetanilides with lithiated methyl salicylates |
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| Authors: | Douglas R Hurst Kristen L French April J Angel Angela R Williams Mary E Rampey Tina S Guion Kam W Chan Camille M Kassis Shannon L Studer Martinez Charles F Beam |
| Abstract: | Several acetoacetanilides were trilithiated in excess lithium diisopropylamide, and the resulting polylithiated intermediates were regioselectively condensed with lithiated methyl salicylates followed by acid cyclization to substituted 4-oxo-N-aryl-4H-1-benzopyran-2-acetamides (benzopyranone-2-acetamides). |
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