Diastereoselective synthesis of cis-3- and 3,5-alkylpyrrolizidines |
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Authors: | Olivier Provot Jean-Pierre Clrier GRard Lhommet |
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Institution: | Olivier Provot,Jean-Pierre Célérier,GÉRard Lhommet |
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Abstract: | Cis-3 and 3,5-substituted pyrrolizidines can be prepared from β-enaminolactones. Substituted pyrrolidinoketones lead to these compounds by an amino reductive annelation with a low diastereomeric excess, but a best access to these azabicycles consists in preparing cis-2,5-disubstituted pyrrolidines which are then transformed into the expected heterocycles. |
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