Synthesis and central nervous system stimulant activity of 5,8-methanoquinazolines fused with 1,2,4-triazole,tetrazoleand 1,2,4-triazine |
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Authors: | Shin-Icbi Nagai Taisei Ueda Satoe Sugiura Akito Nagatsu Nobutoshi Murakami Jinsaku Sakakibara Michiko Fujita Yoshiki Hotta |
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Abstract: | 5,8-Methanoquinazolines fused with 1,2,4-triazole 4–5 , tetrazole 6 , and 1,2,4-triazine 8 were prepared starting from 2-hydrazino-5,8-methanoquinazoline 3 . Compound 3 and 6 showed the most potent central nervous system (CNS) stimulant activities. |
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