Synthesis of 6-cyanopyrido[2,3-d]pyrimidinones in the reaction of 6-amino-4-pyrimidinones with arylidene derivatives of malonodinitrile |
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Authors: | Jairo Quiroga,Mario Alvarado,Braulio Insuasty,Manuel Nogueras,Adolfo S nchez,Justo Cobo |
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Affiliation: | Jairo Quiroga,Mario Alvarado,Braulio Insuasty,Manuel Nogueras,Adolfo Sánchez,Justo Cobo |
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Abstract: | This paper describes the synthesis of a new series of 7-amino-5-aryl-6-cyano-5,8-dihydropyrido-[2,3-d]pyrimidin-4(3H)-ones 3 from the reaction of 6-amino-4-pyrimidinones 1 with arylidene derivatives of malonodinitrile 2 . The structure of the final compounds was determined on the basis of nmr measurements, especially by 1H, 1H-, 1H, 13C COSY, DEPT, HMBC and HMQC experiments. |
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