Metalation of t-butyl sulfoxides,sulfones and sulfonamides of pyridazine and pyrazine. Metalation of diazines. XX |
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Authors: | Alain Turck Nelly Pl Pamla Pollet Guy Quguiner |
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Institution: | Alain Turck,Nelly Plé,Paméla Pollet,Guy Quéguiner |
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Abstract: | In the pyridazine series, the use of tert-butylsulfinyl and tert-butylsulfonyl as ortho directing groups for metalation has been tested. Various functionalized products were obtained in good yields. In the case of 3-tert-butylsulfinyl-6-methoxypyridazine, the metalation was regioselective in ortho to the sulfinyl group. The metalation of 2-tert-butylsulfinyl and 2-tert-butylsulfonylpyrazine gave low to moderate yields. Synthesis of diazinesulfonamides were improved and the metalation of N-tert-butylsulfonamidopyrazine was achieved. |
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