交联壳聚糖膜的制备及其性能的研究

用环氧氯丙烷成功地制备出交联壳聚糖膜。用FTIR,XRD和SEM方法表征其结构,并测试了其力学性能。结果表明,壳聚糖在低温下只有氨基参与交联反应,反应温度高于40℃时,羟基才发生反应;环氧氯丙烷的交联作用显着提高了壳聚糖膜的抗张强度,并有效地降低了溶菌酶对其降解速率;该交联膜有望用作可控降解的生物医用材料。

The Properties and Preparation of Crosslinked Chitosan Films

The crosslinked chitosan films were prepared with epichlorohydrin as a crosslinking agent, and characterized by FTIR, X-ray diffraction and SEM. Their mechanical properties were measured. The structure analysis indicated that at low temperature, the crosslinking reaction only occurred between -NH₂ group of chitosan and epichlorohydrin. When the temperature was above 40 ℃, -OHgroup of chitosan reacted with epichlorohydrin. The results from SEMand measurement of mechanical properties showed that the tensile strength of the crosslinked films was considerably improved, and the rate of degradation of crosslinked films by lysozyme was reduced. The new crosslinked chitosan films are expected to be used as controllable degradation biomaterials.