A stereochemically well-defined rhodium(III) catalyst for asymmetric transfer hydrogenation of ketones |
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Authors: | Matharu Daljit S Morris David J Kawamoto Aparecida M Clarkson Guy J Wills Martin |
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Affiliation: | Asymmetric Catalysis Group, Department of Chemistry, University of Warwick, Coventry, UK. |
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Abstract: | [reaction: see text] A rhodium(III) catalyst for asymmetric transfer hydrogenation of ketones has been designed. The incorporation of a tethering group between the diamino group and the cyclopentadienyl unit provides extra stereochemical rigidity. The catalyst is capable of enantioselective reduction of a range of ketones in excellent ee using formic acid/triethylamine as both the solvent and the reducing agent. |
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