CDK9 inhibitors push cancer cells over the edge |
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| Authors: | Nowicki Matthew W Walkinshaw Malcolm D |
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| Institution: | Centre for Translational and Chemical Biology, University of Edinburgh, King's Buildings, Mayfield Road, Edinburgh EH93JR, Scotland, UK. |
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| Abstract: | The trouble with CDK active-site inhibitors is their tendency to have off-target effects. This is not surprising, as the ATP binding sites of most protein kinases are very similar. Wang et?al. (2010) have used some clever screening approaches to identify selective CDK9 inhibitors that drive cancer cells into apoptosis. |
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