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MOLECULAR ENGINEERING STUDIES ON NONTHROMBOGENIC BIOMATERIALS--A NOVEL CLASS OF NONTHROMBOGENIC BIOMATERIALS WITH ZWITTERIONIC STRUCTURE OF CARBOXYBETAINES
Authors:Jun Zhou  Yong-zhi Qiu  Xiao-peng Zang  Chang-wang Pan  Qiang Chen  Jian Shen  Si-cong Lin
Abstract:N,N-dimethyl-N-methacryloyloxyethyl-N-carboxyethyl ammonium (DMMCA) was graft-copolymerized onto the surface of segmented poly(ether urethane) (SPEU) and PE film. The carboxybetaine structure on SPEU and PE film surfaces was confirmed by ATR-FTIR, XPS and water contact angle measurements. Through the experiments with platelet adhesion and protein adhesion assay in vitro, the two materials studied, including poly-DMMCA gel, all show excellent nonthrombogenicity. This confirms once again that the zwitterionic molecular structure on the surfaces of materials is essential for improving their nonthrombogenicity and biocompatibility.
Keywords:Nonthrombogenic biomaterials  Zwitterionic biomaterial  Carboxybetaine structure  Surface graftcopolymerization  STRUCTURE  ZWITTERIONIC  NONTHROMBOGENIC BIOMATERIALS  CLASS  NOVEL  STUDIES  ENGINEERING  zwitterionic  molecular structure  essential  improving  biocompatibility  show  materials  experiments  platelet adhesion  protein  assay  in vitro  water contact angle
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