| Synthesis of Chlorin—enediyne Dyads by Palladium—catalyzed Coupling Reaction |
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| 引用本文： | 王进军 韩光范 殷军港 邬旭然 赵岩 宫宝安 沈荣基. Synthesis of Chlorin—enediyne Dyads by Palladium—catalyzed Coupling Reaction[J]. 中国化学, 2003, 21(6): 674-679. DOI: 10.1002/cjoc.20030210619 |
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| 作者姓名： | 王进军 韩光范 殷军港 邬旭然 赵岩 宫宝安 沈荣基 |
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| 作者单位： | [1]DepartmentofAppliedChemistry,YantainUniversity,Yantai,Shandong264005,China [2]SchoolofMaterialScienceandEngineering,EastChinaShipbuildingInstitute,Zhenjiang,Jiangsu212003,China [3]BioorganicScienceDivision,KoreaResearchInstituteofTechnology,100Jang-Dong,Yusong-Gu,Taejon305-600,Korea |
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| 基金项目： | ProjectsupportedbytheMinistryoftheScienceandTechnologyofChinaasacooperativeProjectbetweenChinaandKorea ( 2 0 0 2 ) |
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| 摘 要： | Methyl 9-ethylenedioxpyropheophorbide-d was prepared from methyl pyropheophorbide-a by protection of cyclic ketone with ethylene glycol,and oxidation with OsO4 in vinyl group at 2-position.The terminal alkyne was introduced into chlorin chromophore by Grignard reaction,and the enediyne moiety was constructed by a palladium-catalyzed coupling reaction with (Z)-chloroenynes.
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| 关 键 词： | 合成 氯－烯二炔 抗癌药物 光疗法 |
Synthesis of Chlorin-enediyne Dyads by Palladium-catalyzed Coupling Reaction |
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| Wang Jin‐Jun,Yin Jun‐Gang,Wu Xu‐Ran,Zhao Yan,Gong Bao‐An,Han Guang‐Fan,Shim Young Key. Synthesis of Chlorin-enediyne Dyads by Palladium-catalyzed Coupling Reaction[J]. Chinese Journal of Chemistry, 2003, 21(6): 674-679. DOI: 10.1002/cjoc.20030210619 |
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| Authors: | Wang Jin‐Jun Yin Jun‐Gang Wu Xu‐Ran Zhao Yan Gong Bao‐An Han Guang‐Fan Shim Young Key |
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| Abstract: | Methyl 9 ethylenedioxpyropheophorbide d was prepared from methyl pyropheophorbide a by protection of cyclic ketone with ethylene glycol, and oxidation with OsO 4 in vinyl group at 2 position. The terminal alkyne was introduced into chlorin chromophore by Grignard reaction, and the enediyne moiety was constructed by a palladium catalyzed coupling reaction with (Z) chloroenynes. |
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| Keywords: | enediyne chlorin chlorin enediyne dyads photodynamic therapy anticancer agent |
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