新型4-羟基香豆素烯醚衍生物的合成

氮气保护下，以4-羟基香豆素类化合物和2-丁炔酸酯类化合物为原料，1,8-二氮杂二环十一碳-7-烯(DBU)为催化剂，乙腈为溶剂，经Michael加成反应合成了11个新型4-羟基香豆素烯醚衍生物（3a~3k），其结构经¹H NMR， ¹³C NMR， IR和HR-MS（ESI）表征,其构型经H-H NOESY谱确定为Z构型。考察了投料比rn(2-丁炔酸乙酯，2a) : n(4-羟基香豆素，1a)］、溶剂、催化剂、反应温度和反应时间对3a收率的影响。结果表明：在最优条件［r=1.2，乙腈为溶剂，DBU作催化剂，于80 ℃回流反应18 h］下，3a收率最高（70%）。

Synthesis of Novel 4-Hydroxycoumarin Vinyl Ether Derivatives

Eleven novel 4-hydroxycoumarin vinyl ether derivatives(3a ～ 3k) were synthesized by Michael addition of 4-hydroxycoumarins compounds and ethyl 2-butynoate compounds under nitrogen atmosphere using DBU as the catalyst and acetonitrile as solvent.The structures were characterized by 1H NMR,13C NMR,IR and HR-MS(ESI).3a were confirmed to be a Z configuration by H-H NOESY.Effects of molar ratio rn(2a):n(1a)],solvents,catalysts,temperature and reaction time were investigated.The results showed that the highest yield of 3a was 70％ under the optimum conditions r=l.2,DBU as catalyst,reaction in CH3CN at 80 ℃ for 18 h].