Synthesis of pyragonicin |
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Authors: | Strand Daniel Rein Tobias |
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Institution: | KTH Chemistry, Organic Chemistry, SE-100 44 Stockholm, Sweden. |
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Abstract: | structure: see text] A stereocontrolled convergent synthesis of the annonaceous acetogenin pyragonicin (1) is presented. The key intermediates were accessed using asymmetric Horner-Wadsworth-Emmons (HWE) methodology. A reagent controlled zinc-mediated stereoselective coupling, joining the two highly functionalized intermediates 3 and 4, then provided the core structure. |
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