首页 | 本学科首页   官方微博 | 高级检索  
     检索      


Design,synthesis and biological activity against estrogen receptor-dependent breast cancer of furo[1]benzofuran derivatives
Institution:1. College of Pharmacy, Jinzhou Medical University, Jinzhou 121001, China;2. Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China;3. School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
Abstract:The docking study on a series of furo1]benzofuran derivatives with ERα has been demonstrated. The synthesis and characterization of a series of furo1]benzofuran derivatives were described. All the target compounds were conducted to in vitro for the inhibitory activities against human breast cancer strains T-47D, MCF-7 and toxicity against human liver normal cell strains HL7702 via MTT assay. Most of the target compounds possessed anti-estrogen receptor-dependent breast cancer activities with weak toxicity to healthy cell strains. The preliminary structure–activity relationships were discussed.
Keywords:Estrogen receptor  Breast cancer  Inhibitors  Synthesis  Heterocycles  Docking  Furo[1]benzofuran derivatives  DMSO"}  {"#name":"keyword"  "$":{"id":"pc_7Y4vbXkKpd"}  "$$":[{"#name":"text"  "_":"dimethyl sulfoxide  EI"}  {"#name":"keyword"  "$":{"id":"pc_zldakERasR"}  "$$":[{"#name":"text"  "_":"electronic impact  ER"}  {"#name":"keyword"  "$":{"id":"pc_rql0jvuBTw"}  "$$":[{"#name":"text"  "_":"estrogen receptor  ESI"}  {"#name":"keyword"  "$":{"id":"pc_5hv2uDTwDT"}  "$$":[{"#name":"text"  "_":"electrospray ionization  IR"}  {"#name":"keyword"  "$":{"id":"pc_bFrOWIPQkA"}  "$$":[{"#name":"text"  "_":"infrared spectra  LGA"}  {"#name":"keyword"  "$":{"id":"pc_zOsHGdRR26"}  "$$":[{"#name":"text"  "_":"Lamarckian genetic algorithm  MS"}  {"#name":"keyword"  "$":{"id":"pc_PcBynuIlJ0"}  "$$":[{"#name":"text"  "_":"mass spectra  MTT"}  {"#name":"keyword"  "$":{"id":"pc_0RyBX3t8Ai"}  "$$":[{"#name":"text"  "_":"methylthiazolyldiphenyltetrazolium bromide  NMR"}  {"#name":"keyword"  "$":{"id":"pc_J7b8oKCkTL"}  "$$":[{"#name":"text"  "_":"nuclear magnetic resonance spectra  PDB"}  {"#name":"keyword"  "$":{"id":"pc_ffynjdrMct"}  "$$":[{"#name":"text"  "_":"protein data bank  SERMs"}  {"#name":"keyword"  "$":{"id":"pc_aZpQV2sSS1"}  "$$":[{"#name":"text"  "_":"selective estrogen receptor modulators  TBAB"}  {"#name":"keyword"  "$":{"id":"pc_TvauoyDmT4"}  "$$":[{"#name":"text"  "_":"tetrabutylammonium bromide
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号