HPMC crosslinked chitosan/hydroxyapatite scaffolds containing Lemongrass oil for potential bone tissue engineering applications |
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Institution: | 1. Department of Chemistry, The University of Lahore, Lahore, Pakistan;2. Department of Chemistry, Division of Science and Technology, University of Education, Lahore, Pakistan;3. Department of Chemistry College of Sciences, King Khalid University, P.O. Box 9004, Abha, Saudi Arabia;4. Laboratoire des matériaux et de l''environnement pour le développement durable LR18ES10, 9 Avenue Dr.Zoheir Safi, 1006 Tunis, Tunisia;5. Interdisciplinary Research Centre in Biomedical Materials, COMSATS University Islamabad, Lahore Campus, Pakistan;6. Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia |
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Abstract: | The chitosan (CS), hydroxypropyl methyl cellulose (HPMC), hydroxyapatite (HAp and Lemon grass oil (LGO) based scaffolds was prepared by freeze gelation method. The composite formation was confirmed by FTIR (Fourier-transform infrared spectroscopy) analysis and surface morphology was evaluated by SEM (Scanning Electron Microscopy) analysis. The mechanical strength, biodegradation, swelling, porosity and antibacterial activity were evaluated on the basis of LGO contents. The scaffold structure was porous and the mechanical strength was enhanced as a function of LGO contents. The scaffold properties analysis revealed the biodegradation nature and swelling behavior of CS-HPMC-HAp-LGO was also affected significantly as a function of LGO contents. The cytotoxicity of CS-HPMC-HAp-LGO was studied against MC3T3-E1 cells and based on cell viability, no toxic sign was observed. The antimicrobial activity was evaluated against S. aureus and CS-HPMC-HAp-LGO scaffolds showed promising activity, which was varied as a function of LGO contents. The findings revealed that the CS-HPMC-HAp-LGO are biocompatible and have potential for bone tissue engineering. |
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Keywords: | Chitosan Hydroxypropyl methyl cellulose Composite scaffolds Lemongrass essential oil Bioactivity Bone tissue engineering |
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