Measurement and modeling of metoclopramide hydrochloride (anti-emetic drug) solubility in supercritical carbon dioxide |
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| Affiliation: | 1. Department of Chemical Engineering, Faculty of Engineering, University of Kashan, Postal Code: 87317-53153 Kashan, Iran;2. Laboratory of Supercritical Fluids and Nanotechnology, University of Kashan, Postal Code: 87317-53153 Kashan, Iran;3. Modeling and Simulation Centre, Faculty of Engineering, University of Kashan, Postal Code: 87317-53153 Kashan, Iran;4. Department of Chemical and Materials Engineering, National Central University, Taoyuan 320317, Taiwan |
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| Abstract: | Knowledge of drug solubility data in supercritical carbon dioxide (SC-CO2) is a fundamental step in producing nano and microparticles through supercritical fluid technology. In this work, for the first time, the solubility of metoclopramide hydrochloride (MCP) in SC-CO2 was measured in pressure and temperature range of 12 to 27 MPa and 308 to 338 K, respectively. The results represented a range mole fractions of 0.15 × 10-5 to 5.56 × 10-5. To expand the application of the obtained data, six semi-empirical models and three models based on the Peng-Robinson equation of state (PR + VDW, PR + WS + Wilson and PR + MHV1 + COSMOSAC) with different mixing rules and various ways to describe intermolecular interactions were investigated. Furthermore, total enthalpy, sublimation enthalpy and solvation enthalpy relevant to MCP solvating in SC-CO2 were estimated. |
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| Keywords: | Metoclopramide hydrochloride Supercritical carbon dioxide Solubility Sodeifian model Peng-Robinson equation of state |
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