Millettia ferruginea extract attenuates cisplatin-induced alterations in kidney functioning,DNA damage,oxidative stress,and renal tissue morphology |
| |
| Institution: | 1. AgroBioSciences, Mohammed VI Polytechnic University, 43150 Ben-Guerir, Morocco;2. Laboratoire d’Ecologie, de Biologie et de Physiologie des Organismes Aquatiques, LR18ES41, Faculté des Sciences de Tunis, Université Tunis EL Manar, 2092 Tunis, Tunisia;3. Laboratory of Biotechnology and Biomonitoring of the Environment and Oasis Ecosystems, Faculty of Sciences of Gafsa, 2112 Gafsa, Tunisia;4. CHU ibn Eljazar, Unités Chirurgicales les Aglabides Kairouan, Service de Chirurgie Générale, Tunisie;5. Institut Supérieur des Sciences et Technologies de l’Environnement, Université de Carthage, Tunisia;6. Faculté des Sciences de Tunis (UR13/ES25), Université Tunis El - Manar, 2092, Tunis, Tunisia |
| |
| Abstract: | This study aimed to investigate the beneficial role of Millettia ferruginea extract (MF) in preventing cisplatin (Cisp) induced nephrotoxicity in rats. A total of 55 metabolites were identified using LC-MS analysis. The in vivo results indicated that MF pretreatment for 4 weeks (20 mg/kg b.w.) remarkably attenuated the altered renal biomarkers by decreasing the levels of plasma creatinine, urea, and uric acid when compared to the Cisp-group. The nephroprotective capacity of MF was further strengthened by histopathological observations, where Cisp + MF treated rats showed lower number of inflammatory cells and tubular degenerative changes than the Cisp-group. The harmful effects of cisplatin on renal oxidative stress indicators (MDA, SOD, CAT, and GPx), were restored by the treatment of MF. In addition, the reduction of inflammatory markers (IL-6 and TNF-α), associated with alleviating DNA fragmentation, highlighted the preventive effect of MF in kidney tissue. Additionally, MF components presented lower binding energies when docked into the active site of TNF-α and IL-6. The present findings concluded that M. ferruginea extract exhibited nephroprotective potential, which may be attributed to its antioxidant and anti-inflammatory properties. Further work is recommended to confirm the current results, explore the involved mechanism of action, and determine the therapeutic doses and time. |
| |
| Keywords: | Inflammatory Oxidative stress Nephroprotective Antioxidant TBARS"} {"#name":"keyword" "$":{"id":"k0035"} "$$":[{"#name":"text" "_":"Thiobarbituric acid reactive substances MDA"} {"#name":"keyword" "$":{"id":"k0045"} "$$":[{"#name":"text" "_":"Malondialdehyde SOD"} {"#name":"keyword" "$":{"id":"k0055"} "$$":[{"#name":"text" "_":"Superoxide dismutase CAT"} {"#name":"keyword" "$":{"id":"k0065"} "$$":[{"#name":"text" "_":"Catalase GPx"} {"#name":"keyword" "$":{"id":"k0075"} "$$":[{"#name":"text" "_":"Glutathione peroxidase TNF-α"} {"#name":"keyword" "$":{"id":"k0085"} "$$":[{"#name":"text" "_":"Tumor necrosis factor-α IL-6"} {"#name":"keyword" "$":{"id":"k0095"} "$$":[{"#name":"text" "_":"Interleukin 6 gp130"} {"#name":"keyword" "$":{"id":"k0105"} "$$":[{"#name":"text" "_":"glycoprotein 130 IL-6R"} {"#name":"keyword" "$":{"id":"k0115"} "$$":[{"#name":"text" "_":"IL-6 α-receptor mIL-6R"} {"#name":"keyword" "$":{"id":"k0125"} "$$":[{"#name":"text" "_":"Membrane-bound IL-6R sIL-6R"} {"#name":"keyword" "$":{"id":"k0135"} "$$":[{"#name":"text" "_":"Soluble IL-6R b w "} {"#name":"keyword" "$":{"id":"k0145"} "$$":[{"#name":"text" "_":"body weight |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
