| Synthesis,Characterization and in vitro Antitumour Activity of the Di—n—butyltin（IV） Complexes of Some Arylhydroxamates |
| |
| 引用本文： | 魏春英,杨频,等.Synthesis,Characterization and in vitro Antitumour Activity of the Di—n—butyltin（IV） Complexes of Some Arylhydroxamates[J].中国化学,2002,20(5):453-461. |
| |
| 作者姓名： | 魏春英 杨频 |
| |
| 作者单位： | InstituteofMolecularScience,ShanxiUniversity,Taiyuan,Shanxi030006,China |
| |
| 基金项目： | ProjectsupportedbytheNationalNaturalScienceFoundationofChina (No .2 97710 2 3)andtheNaturalScienceFoundationofShanxiProvince |
| |
| 摘 要： | Fourteen new di-n-butyltin(IV)complexes of hydroxamic acids of the formula Bu2SnL2(HL-hydroxamic acids)were synthesized by the reaction of Bu2SnO and hydroxamic acids in dry toluene and ethanol media.The compounds were characterized by elemental analyses,molecular weight,IR and 1H NMR spectoscopy.The results indicate that n-Bu2SnL2 have distorted trans-octahedral structure.The antitumor activity in vitro against human A-549 tumor cells and P388 leukemia was presented,and their structure-activity relationship was discussed.
|
| 关 键 词： | 丁基锡配合物 合成 特征 有机锡化合物 抗癌活性 抗癌药物 |
Synthesis, Characterization and in vitro Antitumour Activity of the Di-n-butyltin(IV) Complexes of Some Arylhydroxamates |
| |
| WEI,Chun Ying YANG,Pin WANG,Lian Hong WANG,Li Institute of Molecular Science,Shanxi University,Taiyuan,Shanxi ,China.Synthesis, Characterization and in vitro Antitumour Activity of the Di-n-butyltin(IV) Complexes of Some Arylhydroxamates[J].Chinese Journal of Chemistry,2002,20(5):453-461. |
| |
| Authors: | WEI Chun Ying YANG Pin WANG Lian Hong WANG Li Institute of Molecular Science Shanxi University Taiyuan Shanxi China |
| |
| Institution: | WEI,Chun Ying YANG,Pin WANG,Lian Hong WANG,Li Institute of Molecular Science,Shanxi University,Taiyuan,Shanxi 030006,China |
| |
| Abstract: | Fourteen new di n butyltin(IV) complexes of hydroxamic acids of the formula Bu 2 SnL 2 (HL=hydroxamic acids) were synthesized by the reaction of Bu 2 SnO and hydroxamic acids in dry toluene and ethanol media. The compounds were characterized by elemental analyses, molecular weight, IR and 1 H NMR spectroscopy. The results indicate that n Bu 2 SnL 2 have distorted trans octahedral structure. The antitumor activity in vitro against human A 549 tumor cells and P388 leukemia was presented, and their structure activity relationship was discussed. |
| |
| Keywords: | diorganotin hydroxamic acid antitumour activity |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
