大型工业液相色谱分离山梨醇和甘露醇过程优化研究

本文采用非线性非平衡含轴向扩散色谱数学模型模拟山梨醇-甘露醇同分异构体系大型工业液相色谱分离过程。首先，通过对分离过程进行参数灵敏度分析，确定了被优参数为进料浓度和色谱柱柱长；然后，以山梨醇的产率为目标函数，限定山梨醇的产品纯度和最小回收率，利用改进的单纯形法对分离过程进行两参数优化，分析了不同进料量和流体线速对最优条件的影响。结果表明：进料量和流体线速对回收率和最大产率的影响程度与参数灵敏度分析结果基本一致，从而证明了利用参数灵敏度分析方法选择色谱分离过程被优参数的可行性。本文还对改进的单纯形法寻优过程进行了探讨，构造了单纯形法优化大型液相色谱的基本方法和框图。

OPTIMIZATION OF LARGE SCALE CHROMATOGRAPHY SEPARATION OF MANNITOL AND SORBITOL

Parameter sensitvity analysis and optimization of the experimental conditions for the separation of mannitol and sorbitol by large -- scale liquid chromatography are investigated. The elution band profiles are calculated using the non -- linear and non -equilibrium model of chromatography. The concentration of injection and column length are selected as optimum parameters by parameter sensitivity analysis, and optimized together using a modified Simplex algorithm (MSM) for the maximum production rate of mannitol, with a purity and recovery constraint. The results of the optimization proved that the method of selecting optimum parameter by parameter sensitivity analysis is feasible. The Simplex optimization process is also studied,the method and frame for the optimizatlon of large-scale chromatography are developed.