A Carbazole-Fused-RhodamineProbe for Detection of HOCl in Living Cells |
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| Authors: | Rui Guo Qiuan Wang Weiying Lin |
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| Institution: | 1.State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering,Hunan University,Changsha,People’s Republic of China;2.Institute of Fluorescent Probes for Biological Imaging, School of Chemistry and Chemical Engineering, School of Materials Science and Engineering,University of Jinan,Jinan,People’s Republic of China |
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| Abstract: | A novel fluorescent probe CR-ClO for detection of HOCl based on a carbazole fused rhodamine was designed and synthesized. The probe utilized a HOCl-promoted oxidation reaction, which lead to the ring opening of the compound with a strong enhancement of the fluorescent emission at about 587 nm.The new probe CR-ClO has excellent selectivity and high sensitivity to ClO?,whose detection limit to ClO? is 1.16 × 10?6 M. Furthermore, the new probe has been successfully applied in living cells for detection of ClO?. |
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