Oxalic Acid: An Efficient and Cost-Effective Organic Catalyst for the Friedländer Quinoline Synthesis under Solvent-Free Conditions |
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Authors: | Minoo Dabiri Mostafa Baghbanzadeh Maryam S Nikcheh |
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Institution: | (1) Department of Chemistry, Faculty of Science, Shahid Beheshti University, Tehran, Iran |
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Abstract: | Summary. Oxalic acid is used as an efficient catalyst in the condensation of 2-aminoaryl ketones with carbonyl compounds leading to
the formation of quinolines in excellent yields under solvent-free conditions. This methodology offers significant improvements
for the synthesis of quinolines with regard to the yield of products, simplicity in operation, inexpensive reagents, and green
aspects by avoiding toxic catalysts and solvents. |
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Keywords: | , Heterocycle, Friedl?nder synthesis, Quinoline, Solvent-free, |
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