| 淀粉样蛋白聚集纤维化的抑制作用研究 |
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| 引用本文： | 王雪松,杜为红,王保怀. 淀粉样蛋白聚集纤维化的抑制作用研究[J]. 中国科学:化学, 2014, 0(6): 822-830 |
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| 作者姓名： | 王雪松 杜为红 王保怀 |
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| 作者单位： | [1]中国人民大学化学系,北京100872 [2]北京大学化学与分子工程学院,北京100871 |
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| 基金项目： | 中国人民大学科学研究基金（中央高校基本科研业务费专项资金资助）项目（14XNH059）支持,特此致谢. |
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| 摘 要： | 总结了不同抑制剂对淀粉样蛋白聚集及纤维化的抑制作用,主要介绍了金属配合物作为淀粉样蛋白抑制剂的研究,并概述了淀粉样蛋白相互作用体系的热力学研究进展.
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| 关 键 词： | 淀粉样蛋白 金属配合物 聚集 热力学 |
Research of the inhibition effects on the fibrillation of amyloid proteins |
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| WANG XueSong,DU WeiHong,WANG BaoHuai. Research of the inhibition effects on the fibrillation of amyloid proteins[J]. Scientia Sinica Chimica, 2014, 0(6): 822-830 |
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| Authors: | WANG XueSong DU WeiHong WANG BaoHuai |
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| Affiliation: | 1 Department of Chemistry, Renmin University of China, Beijing 100872, China ;2 College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China) |
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| Abstract: | This review summarized different kinds of inhibitors that affect the aggregation and fibrillation of amyloid proteins. The metal complexes were optimized as potential and effective inhibitors of amyloid proteins. Moreover, the interaction systems of amyloid proteins were also generalized in the aspect of thermodynamics studies. |
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| Keywords: | amyloid proteins metal complex aggregation thermodynamics |
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