Comparative Pharmacokinetic Study of Forchlorfenuron in Adult and Juvenile Rats |
| |
| Authors: | Li Ping Bingyong Xu Qian Zhou Yawen Hong Qingmei Sun Jincheng Wang Difeng Zhu |
| |
| Affiliation: | 1.Center for Drug Safety Evaluation and Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; (L.P.); (Y.H.); (Q.S.);2.Hangzhou Heze Pharmaceutical Technology Co., Ltd., Hangzhou 310018, China;3.Department of Pharmacy, Hangzhou Medical College, Hangzhou 310053, China; |
| |
| Abstract: | Forchlorfenuron (CPPU) is a plant growth regulator extensively used in agriculture. However, studies on CPPU pharmacokinetics are lacking. We established and validated a rapid, sensitive, and accurate liquid chromatography–mass spectrometry method for CPPU detection in rat plasma. CPPU pharmacokinetics was evaluated in adult and juvenile rats orally treated with 10, 30, and 90 mg/kg of the compound. The area under the plasma drug concentration–time curve from 0 to 24 h (AUC), at the final time point sampled (AUC0–t), and the maximum drug concentration of CPPU increased in a dose-dependent manner. The pharmacokinetic parameters AUC0–t and absolute bioavailability were higher in the juvenile rats than in adult rats. The mean residence time and AUC0–t of juvenile rats in the gavage groups, except for the 10 mg/kg dose, were significantly higher in comparison to those observed for adult rats (p < 0.001). The plasma clearance of CPPU in juvenile rats was slightly lower than that in the adult rats. Taken together, juvenile rats were more sensitive to CPPU than adult rats, which indicates potential safety risks of CPPU in minors. |
| |
| Keywords: | pharmacokinetics forchlorfenuron juvenile rat liquid chromatography-mass spectrometry |
|
|
