Solid-State NMR Spectroscopy: A Key Tool to Unravel the Supramolecular Structure of Drug Delivery Systems |
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Authors: | Marianna Porcino Xue Li Ruxandra Gref Charlotte Martineau-Corcos |
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Institution: | 1.CEMHTI UPR CNRS 3079, Université d’Orléans, 45071 Orléans, France;2.Institut des Sciences Moléculaires d’Orsay, UMR CNRS 8214, Paris-Sud University, Université Paris Saclay, 91400 Orsay, France; (X.L.); (R.G.);3.CortecNet, 7 Avenue du Hoggar, 91940 Les Ulis, France |
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Abstract: | In the past decades, nanosized drug delivery systems (DDS) have been extensively developed and studied as a promising way to improve the performance of a drug and reduce its undesirable side effects. DDSs are usually very complex supramolecular assemblies made of a core that contains the active substance(s) and ensures a controlled release, which is surrounded by a corona that stabilizes the particles and ensures the delivery to the targeted cells. To optimize the design of engineered DDSs, it is essential to gain a comprehensive understanding of these core–shell assemblies at the atomic level. In this review, we illustrate how solid-state nuclear magnetic resonance (ssNMR) spectroscopy has become an essential tool in DDS design. |
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Keywords: | solid-state NMR spectroscopy porous material drug delivery system heteronuclei |
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