Organocatalytic Enantiospecific Total Synthesis of Butenolides |
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| Authors: | Rudrakshula Madhavachary Rosy Mallik Dhevalapally B Ramachary |
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| Institution: | Catalysis Laboratory, School of Chemistry, University of Hyderabad, Central University (P.O.), Gachibowli, Hyderabad 500 046, India; (R.M.); (R.M.) |
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| Abstract: | Biologically important, chiral natural products of butenolides, (−)-blastmycinolactol, (+)-blastmycinone, (−)-NFX-2, (+)-antimycinone, lipid metabolites, (+)-ancepsenolide, (+)-homoancepsenolide, mosquito larvicidal butenolide and their analogues were synthesized in very good yields in a sequential one-pot manner by using an organocatalytic reductive coupling and palladium-mediated reductive deoxygenation or organocatalytic reductive coupling and silica-mediated reductive deamination as the key steps. |
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| Keywords: | butenolides deoxygenation reductive coupling proline total synthesis organocatalysis |
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