Davidones F and G,Two Novel Flavonoids from Sophora davidii (Franch.) Skeels |
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| Authors: | Ping Song Xuecui Li Tongxi Zhou Yu Peng Ho-Young Choi Yuanren Ma Xinzhou Yang |
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| Institution: | 1.School of Chemistry and Chemical Engineering, Qinghai Nationalities University, Xining 810007, China; (P.S.); (X.L.);2.School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China; (T.Z.); (Y.P.);3.College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea; |
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| Abstract: | An unprecedented novel flavanone davidone F (1) with a seven-membered ring side chain, and a novel flavanonol davidone G (2), along with 11 known flavonoids, were isolated from the ethyl acetate fraction of Sophora davidii (Franch.) Skeels. Their planar structures were established by UV, IR, HRESIMS, 1D and 2D NMR data. The relative configurations of 1 and 2 were determined by calculation of NMR chemical shift values, the absolute configuration of 1 and 2 were assigned by comparing their experimental and calculated electronic circular dichroism (ECD) spectra. Moreover, compounds 1–13 were screened for the translocation activity of glucose transporter 4 (GLUT-4), and the fluorescence intensity was increased to the range of 1.56 and 2.79 folds. Compounds 1 and 2 showed moderate GLUT-4 translocation activity with 1.64 and 1.79 folds enhancement, respectively, at a concentration of 20 μg/mL. |
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| Keywords: | Sophora davidii (Franch ) Skeels flavonoids electronic circular dichroism (ECD) glucose transporter 4 (GLUT-4) |
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