Multicomponent Crystal of Metformin and Barbital: Design,Crystal Structure Analysis and Characterization |
| |
Authors: | Linhong Cai Lan Jiang Cong Li Xiaoshu Guan Li Zhang Xiangnan Hu |
| |
Institution: | 1.Department of Medicinal Chemistry, School of Pharmacy, Chongqing Medical University, Chongqing 400016, China; (L.C.); (C.L.); (X.G.); (L.Z.);2.College of Environment and Resources, Chongqing Technology and Business University, Chongqing 400067, China; |
| |
Abstract: | The formation of most multicomponent crystals relies on the interaction of hydrogen bonds between the components, so rational crystal design based on the expected hydrogen-bonded supramolecular synthons was employed to establish supramolecular compounds with desirable properties. This theory was put into practice for metformin to participate in more therapeutic fields to search for a fast and simple approach for the screening of candidate crystal co-formers. The prediction of intermolecular synthons facilitated the successful synthesis of a new multicomponent crystal of metformin (Met) and barbital (Bar) through an anion exchange reaction and cooling crystallization method. The single crystal X-ray diffraction analysis demonstrated the hydrogen bond-based ureide/ureide and guanidine/ureide synthons were responsible for the self-assembly of the primary structural motif and extended into infinite supramolecular heterocatemeric structures. |
| |
Keywords: | multicomponent crystal crystal design supramolecular synthon metformin barbital |
|
|