Interesting transformations of naturally occurring cassane diterpenoids and bioevaluation of the products |
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| Authors: | Chithaluri SudhakarParigi Raghavendar Reddy Tuniki Venugopal RajuBiswanath Das |
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| Institution: | a Organic Chemistry Division-I, Indian Institute of Chemical Technology (CSIR), Hyderabad 500007, India
b NMR Division, Indian Institute of Chemical Technology (CSIR), Hyderabad 500007, India |
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| Abstract: | Two cassane diterpenoids, pulcharrin G (1) and 6β-cinnamoyl-7β-hydroxy-voucapen-5-α-ol (2), the constituents of Caesalpinia pulcherrima, were treated with BF3·OEt2 to furnish two olefinic products 3 and 4, respectively. The products were formed by elimination of water and migration of a methyl group from C-4 to C-5. The cytotoxic and antimicrobial activities of 3 and 4 were examined. |
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| Keywords: | Cassane diterpenoids Chemical modification BF3· OEt2 Cytotoxicity Antimicrobial activity |
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