Asymmetric total synthesis of (S)-dapoxetine |
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| Authors: | Sun Joo KimTae Hong Jeon Im Sook MinIn Su Kim Young Hoon Jung |
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| Institution: | a School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea
b College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea |
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| Abstract: | A concise asymmetric total synthesis of (S)-dapoxetine from commercially available 3-chloropropiophenone is described. The key step includes a highly stereoselective amination of chiral benzylic ether, with the retention of stereochemistry, using chlorosulfonyl isocyanate. |
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| Keywords: | Dapoxetine Chlorosulfonyl isocyanate Amination Asymmetric |
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