Titanium isopropoxide/pyridine mediated Knoevenagel reactions |
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| Authors: | Brian A RobichaudKevin G Liu |
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| Institution: | Chemical & Pharmacokinetic Sciences, Lundbeck Research, Paramus, NJ 07652, United States |
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| Abstract: | We report a Ti(OiPr)4/pyridine-mediated Knoevenagel reaction between aromatic ketones and cyanoacetamides to provide Knoevenagel olefin products in good to excellent yields. Almost in all cases studied, a single geometrical isomer was formed and isolated under the Ti(OiPr)4/pyridine condensation conditions. This methodology was also demonstrated to be highly effective between some other Knoevenagel active methylene compounds and aromatic ketones. |
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| Keywords: | Knoevenagel reaction Knoevenagel condensation Titanium isopropoxide 2-Aminothiophenes Thiophenes |
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