a Department of Applied Chemistry, Kogakuin University, Nakano 2665-1, Hachioji, Tokyo 192-0015, Japan b Hokkaido Pharmaceutical University, School of Pharmacy, Katsuraoka 7-1, Otaru 047-0264, Japan
Abstract:
The C15-C27 segment of venturicidins was stereoselectively synthesized by using two types of stereospecific methyl substitution reactions of epoxides and subsequent stereocontrolled methylation reactions of lactone derivatives as the key steps.