A facile synthesis of perfluoroalkyl vinyl iodides and their palladium-mediated cross-coupling reactions |
| |
| Authors: | Jennings M P Cork E A Ramachandran P V |
| |
| Affiliation: | Herbert C. Brown Center for Borane Research, Department of Chemistry, Purdue University, West Lafayette, Indiana 47907-1393, USA. |
| |
| Abstract: | Catalytic amounts of zinc, as low as 10 mol %, in the presence of trifluoroacetic acid (TFA) initiate the radical addition of perfluoroalkyl iodides to terminal alkynes with high regio- and stereoselectivities. Palladium-mediated cross-coupling of these (E)-perfluoroalkyl vinyl iodides allows for a facile synthesis of potentially useful fluoroorganic intermediates. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
