A general method for synthesis of folic acid, its conjugates and analogues (author's transl)] |
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Authors: | E Khalifa P K Sengupta J H Bieri M Viscontini |
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Abstract: | A general method for synthesis of folic acid, its conjugates and analogues . A new and general method for the synthesis of folic acid, folic acid conjugates and folic acid analogues is described. The key step, i.e. the condensation of N(2′)-acetyl-6-formyl-pterine (I: R1 ? COCH3) with aminoaryl derivatives II, is achieved by refluxing in absolute ethanol to afford the azomethines III. NaBH4-reduction followed by basic hydrolysis gives pure V products in high yield, free from 7-isomers. |
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